Global Bloodstream Diagnostics by Cerebrospinal Fluid Culture Testing Market Research Report - Segmented by Application (Brain Tumor, Neurological Disorder, Central Nervous System Infectious Disease); By End-user (Hospitals Diagnostic Laboratories Others); and Region - Size, Share, Growth Analysis | Forecast (2023 2030)

Market Size and Overview:

The Global Bloodstream Diagnostics by Cerebrospinal Fluid Culture Testing Market was estimated to be worth USD 2.5 Billion in 2022 and is projected to reach a value of USD 4.08 Billion by the end of 2030, growing at a fast CAGR of 6.3% during the forecast period 2023-2030.

The choroid plexus, intricate masses of capillaries located in the lateral, third, and fourth ventricles of the brain, is responsible for secreting cerebrospinal fluid (CSF). The central nervous system (CNS), consisting of the brain and spinal cord, is enveloped and protected by a clear, colorless liquid known as cerebrospinal fluid (CSF). This fluid not only nourishes the brain and spine but also facilitates waste removal and acts as a cushion during trauma to prevent harm. Obtaining CSF for culture involves a lumbar puncture, commonly referred to as a "spinal tap." During this procedure, a medical professional inserts a needle between two lower spine vertebrae to access the CSF surrounding the spinal cord. The collected fluid may be dispensed into a collection vial after the needle is in place, and the process may require more than one vial.

There are alternative methods to obtain CSF, but they are reserved for patients with spinal abnormalities or those unable to undergo a standard lumbar puncture. These methods include placing a needle beneath the occipital bone at the base of the brain or drilling a hole directly through the skull. Once an adequate amount of CSF is collected, it is sent to a laboratory where lab technicians place it on culture media plates. The plates are observed for the proliferation of infectious organisms, and the test is considered negative or normal if no growth is detected. If bacteria, viruses, or fungi are present in the CSF, the test is deemed positive, indicating an infection.

Global Bloodstream Diagnostics by Cerebrospinal Fluid Culture Testing Market Drivers:

The global bloodstream diagnostics by cerebrospinal fluid culture testing market is driven by a high frequency and prevalence of infections affecting the central nervous system and bloodstream:

This suggests an increasing number of individuals are affected by these diseases, potentially leading to severe consequences and even death if untreated. Bloodstream infections, caused by bacteria, fungi, or viruses entering the bloodstream through local infections or contaminated equipment, can result in sepsis, organ failure, and a systemic inflammatory response to infection, ultimately leading to death. Microorganisms infiltrating the brain and spinal cord can cause infections of the central nervous system, manifesting as meningitis or encephalitis and presenting symptoms such as fever, headache, stiff neck, disorientation, convulsions, and coma.

Advancements in cerebrospinal fluid testing and technological improvements drive the global bloodstream diagnostics by cerebrospinal fluid culture testing market:

These advancements indicate that techniques such as polymerase chain reaction (PCR), microarray, proteomic, and mass spectrometry are faster and more accurate than traditional methods like culture and microscopy in detecting and identifying bacteria causing infections in the brain and spinal cord. Additionally, these techniques provide valuable information on the genetic makeup, resistance indicators, and virulence traits of microorganisms, aiding in selecting the most appropriate course of action while limiting the spread of infection.

Global Bloodstream Diagnostics by Cerebrospinal Fluid Culture Testing Market Challenges:

Engaging in cerebrospinal fluid cultures poses risks and drawbacks, encompassing hemorrhage, infection, headache, nerve injury, and brain herniation:

This underscores that the assessment of cerebrospinal fluid is not without peril and may yield adverse outcomes for certain individuals. Hemorrhaging at the lumbar puncture site or within the spinal canal can exert pressure on the spinal cord, leading to neurological complications. Infections, such as meningitis or abscess formation, may arise from needle or cerebrospinal fluid contamination during the procedure. Post lumbar puncture, headaches frequently occur due to the loss of cerebrospinal fluid from the puncture site, resulting in lowered spinal canal pressure. Nerve damage, causing discomfort, numbness, weakness, or paralysis in the lower limbs, can result from injury to the nerve roots during needle insertion. Swift pressure reduction within the skull following cerebrospinal fluid extraction may lead to brain herniation, prompting the brain to shift and compress critical brainstem structures, ultimately causing coma or death.

COVID-19 Impact on Global Bloodstream Diagnostics by Cerebrospinal Fluid Culture Testing Market:

The global COVID-19 pandemic has adversely affected the Cerebrospinal Fluid Drainage Catheter Market. During this period, surgeries related to the brain were routinely postponed or canceled to mitigate the spread of the virus. Substantial declines in neurological surgery rates were observed in severely affected countries, including India, the U.S., Russia, Brazil, France, Italy, the U.K., and Spain. Recommendations to delay or halt elective surgeries were issued by the American College of Surgeons (ACS). Over the past several months, stringent lockdown measures in various countries disrupted the supply chain, delivery schedules, production operations, and sales of cerebrospinal fluid (CSF). However, as countries have begun to ease lockdown restrictions and resume elective procedures, the industry is expected to recover and expand in the coming years. Despite challenges, the global pandemic has also presented new growth opportunities for market participants.

Global Bloodstream Diagnostics by Cerebrospinal Fluid Culture Testing Market Segmentation:

Global Bloodstream Diagnostics by Cerebrospinal Fluid Culture Testing Market Segmentation: By Application

• Brain Tumor
• Neurological Disorder
• Central Nervous System Infectious Disease

The brain tumor sector is expected to claim a significant share in the market due to the increasing global incidence and prevalence of brain tumors, necessitating cerebrospinal fluid culture testing for diagnosis and evaluation. The World Health Organization (WHO) reports approximately 330,000 new cases of cancer of the central nervous system (CNS) and 227,000 CNS cancer-related deaths globally. The central nervous system infectious disease segment is poised to dominate the market, driven by the rising occurrence of infections like meningitis, encephalitis, and neurosyphilis, compelling cerebrospinal fluid culture testing for accurate diagnosis and treatment. WHO estimates around 10.6 million cases of meningitis and 1.2 million fatalities worldwide. The neurological disorder segment is expected to grow significantly due to the escalating prevalence of neurological disorders, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and epilepsy.

Global Bloodstream Diagnostics by Cerebrospinal Fluid Culture Testing Market Segmentation: By End-user

• Hospitals
• Diagnostic Laboratories
• Others

The hospital sector is projected to lead the market as hospitals conduct a substantial number of blood culture tests for the detection and treatment of bloodstream infections and central nervous system infections. Hospitals are well-equipped with advanced tools, resources, and software for efficient and prompt cerebrospinal fluid culture testing. They also possess the essential equipment and trained personnel to conduct cerebrospinal fluid culture testing safely and effectively. The diagnostic labs market sector is anticipated to experience rapid growth due to the increasing demand for cerebrospinal fluid culture testing by both patients and healthcare professionals for early diagnosis and treatment of life-threatening brain and spinal cord infections. Diagnostic laboratories offer cost-effective cerebrospinal fluid culture testing services utilizing traditional and automated methods.

Global Bloodstream Diagnostics by Cerebrospinal Fluid Culture Testing Market Segmentation: By Region

• North America
• Europe
• Asia-Pacific
• South America
• Middle East and Africa

North America is expected to lead the market, driven by a high prevalence of bloodstream infections and central nervous system diseases such as sepsis, meningitis, and encephalitis in the region. The well-established healthcare infrastructure, advanced products, skilled workforce, and favorable reimbursement regulations contribute to the increased demand for cerebrospinal fluid culture testing in North America. Asia-Pacific is predicted to witness significant growth due to the rising incidence of bloodstream infections and diseases of the central nervous system, with the WHO estimating 4.2 million sepsis cases annually in the region.

Key Players:

• Abbott Laboratories
• Becton Dickinson and Company
• Eagle Biosciences, Inc.
• EUROIMMUN Medizinische Labordiagnostika AG
• Eurofins Scientific
• Abcam plc.
• Creative Diagnostics.
• BioFire Diagnostics
• RayBiotech, Inc.
• Quest Diagnostics