Global In Vitro Toxicity Testing Market Research Report - Segmented by Type (Consumables, Services and Assay Kits), By Technology (Cell Culture Technologies, High Throughput technologies, OMICS Technology, Molecular-Imaging, and Others), by Method (Cellular Assays, Bio-Chemical Assays, Ex- Vivo Models, In Silico Models), by End-user Industry (Food Industry, Pharmaceutical Industry, Cosmetics Industry, Household Products, Chemical Industry, Academic Research Laboratories) By Application (Endocrine Disruption, Ocular Toxicity, Dermal Toxicity, Systemic Toxicology, Cytotoxicity, Others); Region Forecast 2024 - 2030.

REPORT DESCRIPTION

Market Size and Overview:

In Vitro Toxicity Testing Market is estimated to be USD 11.1 Billion in 2023 and is projected to grow to USD 23.05 Billion in 2030  at a CAGR of 11.0% from 2024 to 2030.

A key catalyst propelling this market growth is the notable advancements observed in toxicity science. Moreover, the surge in the in-vitro toxicity testing sector is anticipated due to the substantial costs associated with conventional animal testing and the socio-ethical concerns linked with experiments involving animals.

Key Market Insights:

The scientific exploration of the impact of harmful chemical substances on cultured bacteria or mammalian cells is denoted as in vitro toxicity testing. These testing procedures are employed in the initial phases of developing potentially advantageous novel entities, such as therapeutic medications, agricultural chemicals, and food additives. Their purpose is to identify potentially hazardous chemicals and confirm the absence of specific toxic properties. Predominantly used in pharmaceutical development, in vitro toxicity testing assesses the safety and efficacy of new drugs and evaluates compounds based on their potency. Additionally, it aids in measuring drug absorption, distribution, metabolism, and excretion (ADME), dosage response, and threshold response.

Significant advancements in biomedical sciences are anticipated to propel the adoption of advanced and innovative in vitro test methodologies for hazard characterization. The field of toxicology testing is evolving, driven by diverse technologies that enhance the overall procedure. Presently, it stands favorably positioned to leverage upcoming biotechnological revolutions.

Market Drivers:

Rise in Opposition to Animal Testing in Clinical Research:

The European Union enacted regulations in 2004, prohibiting the utilization of animals in testing finished cosmetic products. Subsequent revisions further disallowed the commercialization of cosmetics subjected to animal testing. The escalating resistance to animal usage in pre-clinical research, coupled with breakthroughs in in-vitro toxicology assays, is a pivotal factor propelling the in-vitro Toxicity Testing market's growth.

Increased Focus on Drug Product Safety:

Toxicological testing plays a pivotal role in developing novel medications and enhancing the therapeutic potential of existing compounds. As per the U.S. Food and Drug Administration (FDA), screening novel compounds for pharmacological activity and hazard potential in animals is imperative.

Introduction of New Technologies:

The advent of promising technologies in analytical laboratories and the introduction of novel 3D cell culture approaches hold the potential to elevate the in vitro toxicity testing market. 3D cell culture represents a significant milestone in the in vitro toxicity testing market.

Market Restraints:

The reluctance of regulatory authorities to consider alternative approaches for demonstrating safety and efficacy poses a restraint on the market. Despite the growing emphasis on non-animal-based testing procedures, some countries exhibit a hesitancy to transition from in vivo to in vitro methods, even after the latter has demonstrated superior scientific significance.

COVID-19 Impact on Global In vitro Toxicity Testing Market

The exponential growth of the COVID-19 outbreak since 2020 has resulted in a notable decline in routine patient visits to healthcare facilities and a reduction in the completion of profile studies under normal conditions. This is expected to hinder market expansion to some extent. However, the pandemic's impact on raw material supplies for in vitro toxicology technologies has been minimal, with stabilization in the global economy anticipated to gradually revive diagnostic procedures and pipeline drugs, contributing to market growth in in vitro toxicity testing.

Segment Analysis

The segmentation of the Global In-vitro Toxicity Testing Market is organized based on type, technology, method, end-user industry, and region.

In vitro Toxicity Testing Market Segmentation - By Type

• Consumables
• Services
• Assays Kits
• Bacterial Toxicity Assays
• Enzyme Toxicity Assays
• Cell-based Elisa & Western Blots
• Receptor-binding Assays
• Tissue Culture Assays
• Others

In the year 2022, consumables are anticipated to be the most lucrative segment of the in vitro toxicity testing market. The substantial share of this segment is attributed to the increasing demand for high-quality reagents and the frequent use of media in in vitro toxicity investigations.

In vitro Toxicity Testing Market Segmentation - By Technology

• Cell Culture Technologies
• High Throughput Technologies
• OMICS Technology
• Molecular Imaging
• Others

Cell-culture technology is forecasted to dominate the global market. Recognized as an excellent model for screening toxic effects, this technology consistently delivers reliable results.

In vitro Toxicity Testing Market Segmentation - By Method

• Cellular Assays
• Bio-Chemical Assays
• Ex- Vivo Models
• In Silico Models

Due to rapid adoption and technological advancements, in silico models and ex-vivo models have emerged as current trends in the in vitro toxicity testing market, exhibiting significant growth potential by 2027.

In 2021, cellular assays are estimated to hold the largest share of the entire in-vitro toxicity testing market. Offering faster, more efficient, and cost-effective toxicity detection compared to biochemical and ex vivo methods, cellular assays enable the detection and measurement of cell viability, functioning, and proliferation. These assays, with advancements in cell-based technologies, are expected to further boost the market.

In vitro Toxicity Testing Market Segmentation - By End-user Industry

• Food Industry
• Pharmaceutical Industry
• Cosmetics Industry
• Household Products
• Chemical Industry
• Academic Research Laboratories

The pharmaceutical and biopharmaceuticals sector is anticipated to dominate the in vitro toxicity testing market, playing a pivotal role in medication development.

The cosmetics industry's growing popularity, driven by increased disposable incomes and demand for cruelty-free products, is fostering breakthrough research and development, further propelling the in vitro toxicity testing market.

Continuous advancements in toxicity profiling are expected to increase the application of in vitro models in the chemical industry.

In vitro Toxicity Testing Market Segmentation - By Application

• Endocrine Disruption
• Ocular Toxicity
• Dermal Toxicity
• Systemic Toxicology
• Cytotoxicity
• Others

Technological advancements in dermal toxicity and risk assessment tools are estimated to drive segment growth globally. The systemic toxicity segment is expected to hold the major share of the global in vitro testing market due to its assessment of toxicity across multiple organs.

In vitro Toxicity Testing Market Segmentation - Regional Analysis

• North America
• Europe
• Asia Pacific
• South America
• Middle East and Africa

North America: With increased government focus on drug discovery, rising healthcare expenditure, and adequate infrastructure, North America dominated the in-vitro toxicity testing market, accounting for the largest revenue share in 2023.

Europe: The in-vitro toxicity testing market in Europe is predicted to grow at a CAGR of 12.9% from $XX Mn in 2021, driven by increased healthcare awareness, higher per-capita income and expenditure, and enhanced healthcare infrastructure.

Asia-Pacific: The in vitro toxicology testing market in Asia Pacific is expected to witness the fastest rate of development during the forecast period. This is attributed to the emergence of Contract Research Organizations (CROs), opposition to animal testing, an expanding pharmaceutical drug pipeline, and rising consumer awareness of product safety.

Rest of the World: The Middle East and Africa region are expected to experience minimal growth in the in vitro toxicity testing market, primarily due to advancements in various analytical methods over biotechnology. These regions contribute to nearly 2/5th of the overall B2B operational activities of the global In-Vitro Toxicity Testing market.

Key Players of Global In Vitro Toxicity Testing Market:

• Merck KGaA
• Charles River
• Bio-Rad Laboratories, Inc.
• Thermo Fisher Scientific Inc.
• Catalent, Inc.
• General Electric Company
• Quest Diagnostics Incorporated
• Eurofins Scientific SE
• Laboratory Corporation of America Holdings
• Agilent Technologies, Inc.

Market and Developments:

• Covance launched a new R&D center in Shanghai, China, aimed at fostering growth in the in vitro toxicity testing industry in the Asia Pacific region.
• Abbott and Intoximeters entered into an agreement to commercialize Abbott's SoToxa Mobile Test System, a handheld oral fluid solution for alcohol and drug testing in the United States, covering testing for benzodiazepines, methamphetamine, amphetamine, cocaine, opiates, and cannabis.